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Method for optical coherence elastography of the cornea
- Source :
- Journal of Biomedical Optics. 16:016005
- Publication Year :
- 2011
- Publisher :
- SPIE-Intl Soc Optical Eng, 2011.
-
Abstract
- The material properties of the cornea are important determinants of corneal shape and refractive power. Corneal ectatic diseases, such as keratoconus, are characterized by material property abnormalities, are associated with progressive thinning and distortion of the cornea, and represent a leading indication for corneal transplantation. We describe a corneal elastography technique based on optical coherence tomography (OCT) imaging, in which displacement of intracorneal optical features is tracked with a 2-D cross-correlation algorithm as a step toward nondestructive estimation of local and directional corneal material properties. Phantom experiments are performed to measure the effects of image noise and out-of-plane displacement on effectiveness of displacement tracking and demonstrated accuracy within the tolerance of a micromechanical translation stage. Tissue experiments demonstrate the ability to produce 2-D maps of heterogeneous intracorneal displacement with OCT. The ability of a nondestructive optical method to assess tissue under in situ mechanical conditions with physiologic-range stress levels provides a framework for in vivo quantification of 3-D corneal elastic and viscoelastic resistance, including analogs of shear deformation and Poisson’s ratio that may be relevant in the early diagnosis of corneal ectatic disease.
- Subjects :
- Keratoconus
Materials science
genetic structures
medicine.medical_treatment
Research Papers: Imaging
Biomedical Engineering
Sensitivity and Specificity
Imaging phantom
Cornea
Biomaterials
Elasticity Imaging Techniques
Optics
Optical coherence tomography
medicine
Humans
Optical tomography
Corneal transplantation
medicine.diagnostic_test
business.industry
Ophthalmoscopes
Reproducibility of Results
Equipment Design
medicine.disease
eye diseases
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Equipment Failure Analysis
medicine.anatomical_structure
sense organs
Elastography
business
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 10833668
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....f10998f771479afb1903f1d694d090cd