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Nickel‐Catalyzed Reductive Coupling for Transforming Unactivated Aryl Electrophiles into β‐Fluoroethylarenes
- Source :
- Chemistry – An Asian Journal. 15:156-162
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- We report herein a facile synthetic method for converting unactivated (hetero)aryl electrophiles into β-fluoroethylated (hetero)arenes via nickel-catalyzed reductive cross-couplings. This coupling reaction features the involvement of FCH2 CH2 radical intermediate rather than β-fluoroethyl manganese species which provides effective solutions to the problematic β-fluoride side eliminations. The practical value of this protocol is further demonstrated by the late-stage modification of several complex ArCl or ArOH-derived bioactive molecules.
- Subjects :
- 010405 organic chemistry
Bioactive molecules
Aryl
Organic Chemistry
chemistry.chemical_element
macromolecular substances
General Chemistry
Manganese
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
Coupling reaction
0104 chemical sciences
Catalysis
Coupling (electronics)
Nickel
chemistry.chemical_compound
chemistry
Electrophile
Subjects
Details
- ISSN :
- 1861471X and 18614728
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Chemistry – An Asian Journal
- Accession number :
- edsair.doi.dedup.....f10911f344264dd2280e38a7ecd84344