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Fibroblast growth factor 10 is required for proper development of the mouse whiskers
- Source :
- Biochemical and Biophysical Research Communications. 302:562-567
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse.
- Subjects :
- Patched
medicine.medical_specialty
Time Factors
animal structures
Mesenchyme
Whiskers
Biophysics
Mice, Transgenic
Fibroblast growth factor
Biochemistry
Mesoderm
Mice
Whisker
Internal medicine
medicine
Animals
Hedgehog Proteins
Sonic hedgehog
Molecular Biology
Mice, Knockout
FGF10
integumentary system
biology
Chemistry
Cell Biology
Hair follicle
Cell biology
Fibroblast Growth Factors
stomatognathic diseases
Phenotype
medicine.anatomical_structure
Endocrinology
Vibrissae
Microscopy, Electron, Scanning
Trans-Activators
biology.protein
Fibroblast Growth Factor 10
Signal Transduction
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 302
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....f10358868238463acb3a98192f281585