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Aspirin Triggered Resolvin D1 reduces inflammation and restores saliva secretion in a Sjögren's syndrome mouse model
- Source :
- Rheumatology (Oxford, England). 58(7)
- Publication Year :
- 2018
-
Abstract
- Objectives SS is characterized by chronic inflammation of the salivary glands leading to loss of secretory function, thereby suggesting specialized pro-resolving mediators targeting inflammation to be a viable option for treating SS. Previous studies demonstrated that aspirin-triggered resolvin D1 (AT-RvD1) prevents chronic inflammation and enhances saliva secretion in a SS-like mouse model when applied before disease onset. However, this therapy cannot be used in SS patients given that diagnosis occurs post-disease onset and no reliable screening methods exist. Therefore, we examined whether treatment with AT-RvD1 reduces SS-like features in a mouse model post-disease onset. Methods Tail vein injections were performed in a SS-like mouse model both with and without AT-RvD1 post-disease onset for 8 weeks, with salivary gland function and inflammatory status subsequently determined. Results Treatment of a SS-like mouse model with AT-RvD1 post-disease onset restores saliva secretion in both females and males. Moreover, although AT-RvD1 treatment does not reduce the overall submandibular gland lymphocytic infiltration, it does reduce the number of T helper 17 cells within the infiltrates in both sexes. Finally, AT-RvD1 reduces SS-associated pro-inflammatory cytokine gene and protein expression levels in submandibular glands from female but not male mice. Conclusion AT-RvD1 treatment administered post-disease onset reduces T helper 17 cells and successfully restores salivary gland function in a SS mouse model with variable effects noted by sex, thus warranting further examination of both the causes for the sex differences and the mechanisms responsible for the observed treatment effect.
- Subjects :
- Male
medicine.medical_specialty
Docosahexaenoic Acids
Lymphocyte
medicine.medical_treatment
Saliva secretion
Drug Evaluation, Preclinical
Inflammation
Formyl peptide receptor 2
03 medical and health sciences
0302 clinical medicine
Rheumatology
Mice, Inbred NOD
Internal medicine
medicine
Animals
Pharmacology (medical)
030212 general & internal medicine
Lymphocyte Count
Saliva
030203 arthritis & rheumatology
Aspirin
Basic and Translational Science
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Submandibular gland
Disease Models, Animal
Endocrinology
medicine.anatomical_structure
Cytokine
Sjogren's Syndrome
Cytokines
Th17 Cells
Female
Interleukin 17
medicine.symptom
Inflammation Mediators
business
Salivation
medicine.drug
Subjects
Details
- ISSN :
- 14620332
- Volume :
- 58
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Rheumatology (Oxford, England)
- Accession number :
- edsair.doi.dedup.....f0fdddae6fba131fc8fd07b7b964634c