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A widespread self-cleaving ribozyme class is revealed by bioinformatics
- Source :
- Nature chemical biology
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Ribozymes are noncoding RNAs that promote chemical transformations with rate enhancements approaching those of protein enzymes. Although ribozymes are likely to have been abundant during the RNA world era, only ten classes are known to exist among contemporary organisms. We report the discovery and analysis of an additional self-cleaving ribozyme class, called twister, which is present in many species of bacteria and eukarya. Nearly 2,700 twister ribozymes were identified that conform to a secondary structure consensus that is small yet complex, with three stems conjoined by internal and terminal loops. Two pseudoknots provide tertiary structure contacts that are critical for catalytic activity. The twister ribozyme motif provides another example of a natural RNA catalyst and calls attention to the potentially varied biological roles of this and other classes of widely distributed self-cleaving RNAs.
- Subjects :
- 010402 general chemistry
Bioinformatics
01 natural sciences
Article
Protein Structure, Secondary
03 medical and health sciences
RNA, Catalytic
Molecular Biology
Ligase ribozyme
030304 developmental biology
Genetics
0303 health sciences
biology
Hydrolysis
Ribozyme
Computational Biology
Cell Biology
Group II intron
Hydrogen-Ion Concentration
0104 chemical sciences
GlmS glucosamine-6-phosphate activated ribozyme
Metals
biology.protein
Mammalian CPEB3 ribozyme
Hairpin ribozyme
Pseudoknot
VS ribozyme
Subjects
Details
- ISSN :
- 15524469 and 15524450
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Nature Chemical Biology
- Accession number :
- edsair.doi.dedup.....f0f8fbaefbb86b00848e422f17e091c7