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Combined effects of moderate exercise and short-term fasting on markers of immune function in healthy human subjects
- Source :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 318:R1103-R1115
- Publication Year :
- 2020
- Publisher :
- American Physiological Society, 2020.
-
Abstract
- This study aimed to investigate the effects of a short-term (36 h) fasting period combined with an acute bout of exercise on markers of immune function and inflammation in healthy human subjects. Fourteen moderately trained male subjects (aged 19–39 yr) participated in a 36-h fasting trial (FA-T), followed by an acute bout of moderate exercise (60% V̇o2max). After 1 wk, the same subjects, as their own control, participated in a nonfasting trial (NFA-T) in which they performed an exercise trial of the same duration and intensity. Blood samples were taken before, immediately after, and 1 h after each exercise bout and analyzed for several immunological and metabolic markers. At baseline, fasting subjects showed lower levels of T cell apoptosis, lymphocyte-proliferative responses, IL-6, monocyte chemoattractant protein-1 (MCP-1), insulin, and leptin ( P < 0.05) as well as higher levels of neutrophil oxidative burst and thiobarbituric acid reactive substances (TBARS) than those in the NFA-T ( P < 0.05). After the exercise protocol, fasted subjects revealed higher T cell apoptosis, neutrophil oxidative burst, TBARS, TNFα, and MCP-1 levels as well as lower levels of lymphocyte-proliferative response, IL-6, insulin, and leptin than those in the NFA-T ( P < 0.05). Short-term fasting aggravates perturbations in markers of immune function, and inflammation was induced by an acute moderate-intensity exercise protocol.
- Subjects :
- Adult
Leptin
Male
0301 basic medicine
medicine.medical_specialty
Physiology
Thiobarbituric acid
Lymphocyte
medicine.medical_treatment
Apoptosis
Inflammation
Thiobarbituric Acid Reactive Substances
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Physiology (medical)
Internal medicine
medicine
TBARS
Humans
Insulin
Exercise
Chemokine CCL2
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Fasting
030229 sport sciences
Healthy Volunteers
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
Tumor necrosis factor alpha
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 15221490 and 03636119
- Volume :
- 318
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Accession number :
- edsair.doi.dedup.....f0f43c5e0f4b3b02729679ddeeb708fa