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Angiosarcoma with dermal melanocytosis
- Source :
- Journal of Cutaneous Pathology. 16:149-153
- Publication Year :
- 1989
- Publisher :
- Wiley, 1989.
-
Abstract
- We report a case of angiosarcoma and dermal melanocytosis occurring simultaneously in the same lesion. We examined the primary and 2 metastatic lesions. Histopathologically, the anaplastic angiosarcoma cells had a tendency to form irregularly shaped small cavities. Immunohistochemically, they were strongly reactive with Ulex europaeus agglutinin (UEAI) stain. The mid and deep dermis of the same lesion had spindle or elongated slender melanocytes containing melanin granules. The melanocytes were positive with S-100 protein stain. Ultrastructurally, pinocytotic vesicles, fine filaments, and Weibel-Palade body-like dense granules were observed in the cytoplasm of angiosarcoma cells. Dermal melanocytes had external lamina and melanosomes in various stages. The melanocytes showed no similarity to the neoplastic tumor cells and there was no apparent intermediate form between the 2 kinds of cells. The etiological implications of dermal melanocytosis with a tumor of vascular origin are discussed.
- Subjects :
- Pathology
medicine.medical_specialty
Skin Neoplasms
Histology
Hemangiosarcoma
Dermatology
Biology
Stain
Pathology and Forensic Medicine
Foot Diseases
Melanin
Lesion
Dermis
Lectins
medicine
Humans
Angiosarcoma
Skin
Melanosome
Staining and Labeling
Middle Aged
Immunohistochemistry
External lamina
Microscopy, Electron
medicine.anatomical_structure
Melanocytes
Female
Plant Lectins
medicine.symptom
Cell Division
Subjects
Details
- ISSN :
- 16000560 and 03036987
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Cutaneous Pathology
- Accession number :
- edsair.doi.dedup.....f0ee300657a11dcc887f31156b17b906