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Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans
- Publication Year :
- 2018
- Publisher :
- Taylor & Francis, 2018.
-
Abstract
- The objectives of this study were to determine the absolute bioavailability of lesinurad and to characterized its disposition in humans.The oral bioavailability assessment was performed using a clinical design of simultaneous dosing of a therapeutic oral dose of lesinurad with an intravenous infusion of [14C]lesinurad microdose. The bioavailability of lesinurad was determined to be 100%.The disposition of lesinurad in humans involves hepatic oxidation and renal elimination following administration of oral [14C]lesinurad dose.Metabolism of lesinurad occurred post-systemically with low circulating levels of metabolites 14C]lesinurad microdose. The bioavailability of lesinurad was determined to be 100%. The disposition of lesinurad in humans involves hepatic oxidation and renal elimination following administration of oral [14C]lesinurad dose. Metabolism of lesinurad occurred post-systemically with low circulating levels of metabolites
- Subjects :
- Adult
Male
Health, Toxicology and Mutagenesis
Biological Availability
Pharmacology
Toxicology
030226 pharmacology & pharmacy
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
MicroDose
Humans
Infusions, Intravenous
CYP2C9
Cytochrome P-450 CYP2C9
Reabsorption
Lesinurad
General Medicine
Metabolism
Triazoles
Bioavailability
Uric Acid
Renal Elimination
chemistry
030220 oncology & carcinogenesis
Thioglycolates
Uric acid
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f0da87449db7d22ea69ac371209d0759
- Full Text :
- https://doi.org/10.6084/m9.figshare.7076906