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Multiple-CT optimization of intensity-modulated proton therapy – Is it possible to eliminate adaptive planning?
- Source :
- Radiotherapy and Oncology. 128:167-173
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Background and purpose We hypothesized that a plan’s robustness to anatomical changes can be improved by optimizing with multiple CT scans of a patient. The purpose of this study was to determine whether an intensity modulated proton therapy (IMPT) plan could be developed to meet dose criteria on both planning and adaptive CT plans. Material and methods Eight lung cancer patients who underwent adaptive IMPT were retrospectively selected. Each patient had two CTs: a primary planning CT (PCT) and an adaptive planning CT (ACT), and IMPT plans associated with the scans. PCT and ACT were then used in combination to optimize one plan (MCT plan). The doses to the target and organs at risk from the PCT plan, ACT plan, P-ACT plan (PCT plan calculated on ACT data), and MCT plans calculated on both CTs were compared. Results The MCT plan maintained the D 95% on both CTs (mean, 65.99 Gy on PCT and 66.02 Gy on ACT). Target dose coverage on ACT was significantly better with the MCT plan than with the P-ACT plan ( p = 0.01). MCT plans had slightly higher lung V 20 (0.6%, p = 0.02) than did PCT plans. The various plans showed no statistically significant difference in heart and spinal cord dose. Conclusions The results of this study indicate that an IMPT plan can meet the dose criteria on both PCT and ACT, and that MCT optimization can improve the plan’s robustness to anatomical change.
- Subjects :
- Male
Organs at Risk
Lung Neoplasms
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Adaptive planning
Proton Therapy
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Proton therapy
Aged
Retrospective Studies
business.industry
Radiotherapy Planning, Computer-Assisted
Significant difference
Radiotherapy Dosage
Hematology
Middle Aged
Intensity (physics)
Target dose
Oncology
030220 oncology & carcinogenesis
Female
Radiotherapy, Intensity-Modulated
Tomography, X-Ray Computed
business
Nuclear medicine
Subjects
Details
- ISSN :
- 01678140
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- Radiotherapy and Oncology
- Accession number :
- edsair.doi.dedup.....f0d8e914c4e737645c6f9c87d10e6cb5