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Optimizing clinical utilization and allocation of older kidneys
- Source :
- Current Opinion in Organ Transplantation. 20:431-437
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- PURPOSE OF REVIEW With a persisting organ shortage and constant high discard rates, there is an urgent need to optimize the outcome and allocation of marginal grafts. RECENT FINDINGS The Eurotransplant Senior Program was established as an 'old-for-old' allocation system emphasizing on the importance of keeping ischemic times short when utilizing marginal grafts. In addition to refined allocation systems, brief cold ischemic times, novel preservation techniques, a careful assessment of organ quality the utilization of dual kidney transplantation and donation after cardiac death kidneys from elderly donors may all help to increase the supply for renal transplantation. Moreover, age-adapted immunosuppression, improved patient selection and preparation for transplantation may help in improving outcomes when using marginal kidneys. SUMMARY There is a significant potential to increase the utilization of marginal grafts with reduced discard rates, an increased utilization of dual kidney transplantation and the application of novel preservation methods.
- Subjects :
- Aging
Transplantation
Dual kidney transplantation
medicine.medical_specialty
Preservation methods
business.industry
Patient Selection
medicine.medical_treatment
Donation after cardiac death
Economic shortage
Immunosuppression
Organ Preservation
Kidney
Kidney Transplantation
Tissue Donors
medicine
Humans
Immunology and Allergy
business
Intensive care medicine
Subjects
Details
- ISSN :
- 10872418
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Organ Transplantation
- Accession number :
- edsair.doi.dedup.....f0d7a1bfce44758ce7a35224a7fcb139