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Serum immunosuppressive acidic protein in adult T-cell leukaemia (ATL)
- Source :
- Scandinavian journal of haematology. 34(5)
- Publication Year :
- 1985
-
Abstract
- The availability of serum immunosuppressive acidic protein (IAP) as a marker of subtypes of adult T-cell leukaemia (ATL) was examined. Serum IAP levels were measured in 34 patients with ATL (18 typical, 9 atypical and 7 smoldering), 7 healthy carriers of ATLA antibody and 53 healthy controls. The mean value of serum IAP was significantly higher in patients with typical ATL (897.8 +/- 502.4 micrograms/ml) than in those with atypical ATL (426.7 +/- 106.6 micrograms/l), smoldering ATL (310.0 +/- 51.3 micrograms/ml), healthy carriers of ATLA antibody (302.9 +/- 39.5 micrograms/ml) and normal controls (350.5 +/- 73.2 micrograms/ml). Serial determinations of IAP revealed that the level was correlated with the clinical course in patients with ATL; there was a difference in the prognosis of patients with high and normal levels of IAP (P less than 0.05). Thus, routine measurement of serum IAP seems useful in differentiating typical, atypical and smoldering ATL and also in evaluating the prognosis of patients.
- Subjects :
- Adult
Male
viruses
medicine.medical_treatment
Microgram
T-Lymphocytes
Antigen-Antibody Complex
Biology
Immunosuppressive acidic protein
hemic and lymphatic diseases
medicine
Humans
Adult T-cell leukaemia
Aged
Leukemia
L-Lactate Dehydrogenase
Immunosuppression
Hematology
T lymphocyte
Middle Aged
medicine.disease
Immune complex
Neoplasm Proteins
Immunology
biology.protein
Calcium
Female
Antibody
Subjects
Details
- ISSN :
- 0036553X
- Volume :
- 34
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Scandinavian journal of haematology
- Accession number :
- edsair.doi.dedup.....f0cc89a5d51e17bbfc9455aee40327c0