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Extracellular Release of Antigen by Dendritic Cell Regurgitation Promotes B Cell Activation through NF-κB/cRel
- Source :
- Journal of Immunology, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2020, 205 (3), pp.608-618. ⟨10.4049/jimmunol.1900394⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Dendritic cells (DCs) are professional APCs, which sample Ags in the periphery and migrate to the lymph node where they activate T cells. DCs can also present native Ag to B cells through interactions observed both in vitro and in vivo. However, the mechanisms of Ag transfer and B cell activation by DCs remain incompletely understood. In this study, we report that murine DCs are an important cell transporter of Ag from the periphery to the lymph node B cell zone and also potent inducers of B cell activation both in vivo and in vitro. Importantly, we highlight a novel extracellular mechanism of B cell activation by DCs. In this study, we demonstrate that Ag released upon DC regurgitation is sufficient to efficiently induce early B cell activation, which is BCR driven and mechanistically dependent on the nuclear accumulation of the transcription factor NF-κB/cRel. Thus, our study provides new mechanistic insights into Ag delivery and B cell activation modalities by DCs and a promising approach for targeting NF-κB/cRel pathway to modulate the DC-elicited B cell responses.
- Subjects :
- [SDV]Life Sciences [q-bio]
Immunology
Cell
Mice, Transgenic
Lymphocyte Activation
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Antigen
In vivo
medicine
Extracellular
Immunology and Allergy
Animals
Antigens
Transcription factor
B cell
ComputingMilieux_MISCELLANEOUS
Antigen Presentation
B-Lymphocytes
NF-kappa B
NF-κB
Dendritic cell
Dendritic Cells
Proto-Oncogene Proteins c-rel
3. Good health
Cell biology
medicine.anatomical_structure
chemistry
Female
030215 immunology
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 00221767 and 15506606
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2020, 205 (3), pp.608-618. ⟨10.4049/jimmunol.1900394⟩
- Accession number :
- edsair.doi.dedup.....f0c3a6c218e32cebcd46eb1d529172c3