Back to Search
Start Over
Collagen distribution in the lamina cribrosa and the trabecular meshwork of the human eye
- Source :
- British Journal of Ophthalmology. 71:886-892
- Publication Year :
- 1987
- Publisher :
- BMJ, 1987.
-
Abstract
- Tengroth and Ammitzböll found the collagen content of the optic disc in glaucoma to differ from that of normal eyes. A theory was advanced that a primary collagen disturbance might be involved in the pathogenesis of glaucoma. The connective tissue in the body has a supportive function in almost all the organs. The tensile strength and elasticity of connective tissue is mainly due to the presence of collagen fibres and elastic fibres, which also maintain the shape of the tissues. There are many different types of collagen, three of which are discussed in this paper. Type I collagen is found in tendons, skin, and numerous other organs, for example the eye. Type III is found mainly in the blood vessels but is also present in other tissues with a mesodermal origin, and type IV is found in the basement membranes. To elucidate the precise distribution of collagen types in the ocular structures an immunhistochemical study was undertaken in normal human eyes. The amino acids proline, hydroxyproline, and hydroxylysine, which are characteristic of collagen, were also analysed. Collagen types I, III, and IV were found in the lamina cribrosa, the trabecular meshwork, and the retrolaminary optic nerve. In contrast, only type I was found in the sclera.
- Subjects :
- Reticular fiber
Proline
genetic structures
Connective tissue
Hydroxylysine
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Hydroxyproline
Trabecular Meshwork
medicine
Humans
business.industry
Optic Nerve
Anatomy
Middle Aged
eye diseases
Sensory Systems
Sclera
Ophthalmology
Collagen, type I, alpha 1
medicine.anatomical_structure
chemistry
Collagen
sense organs
Trabecular meshwork
business
Type I collagen
Research Article
Subjects
Details
- ISSN :
- 00071161
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....f0bab16e53883469285a82b3a7328f47