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Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets
- Source :
- American Society of Clinical Oncology Educational Book. :825-832
- Publication Year :
- 2017
- Publisher :
- American Society of Clinical Oncology (ASCO), 2017.
-
Abstract
- Otto Warburg’s discovery in the 1920s that tumor cells took up more glucose and produced more lactate than normal cells provided the first clues that cancer cells reprogrammed their metabolism. For many years, however, it was unclear as to whether these metabolic alterations were a consequence of tumor growth or an adaptation that provided a survival advantage to these cells. In more recent years, interest in the metabolic differences in cancer cells has surged, as tumor proliferation and survival have been shown to be dependent upon these metabolic changes. In this educational review, we discuss some of the mechanisms that tumor cells use for reprogramming their metabolism to provide the energy and nutrients that they need for quick or sustained proliferation and discuss the potential for therapeutic targeting of these pathways to improve patient outcomes.
- Subjects :
- 0301 basic medicine
Tumor cells
Therapeutic targeting
Article
03 medical and health sciences
0302 clinical medicine
Neoplasms
medicine
Humans
Survival advantage
Tumor growth
Cell Proliferation
business.industry
Cancer
General Medicine
Metabolism
Cellular Reprogramming
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Energy Metabolism
business
Reprogramming
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 15488756 and 15488748
- Database :
- OpenAIRE
- Journal :
- American Society of Clinical Oncology Educational Book
- Accession number :
- edsair.doi.dedup.....f0b98d6430452a2d51a9f9afbf736df1