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Neutrophil Adhesion and Activation during Systemic Thrombolysis in Acute Myocardial Infarction
- Source :
- Thrombosis Research. 91:183-190
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- In a pilot study, alterations of polymorphonuclear neutrophil function during systemic thrombolysis in acute myocardial infarction have been investigated in humans. The following parameters of neutrophil function were measured before and at 15 and 45 minutes after initiation of systemic thrombolysis with a recombinant tissue-type plasminogen activator in 20 patients with acute myocardial infarction: (1) neutrophil adhesion and (2) neutrophil activation. During systemic thrombolysis a significant decrease was observed in neutrophil adhesion (5.5+/-6.4 to 3.2+/-3.3; p0.05), in phagocyting neutrophil activation (39+/-18 to 25+/-14%; p0.05), and in resting neutrophil activation (9+/-7 to 3+/-4%; p0.05). Successful reperfusion coincided with a significantly higher reduction of phagocyting neutrophil activation (40+/-14 to 20+/-12% vs. 39+/-24 to 26+/-19% in unsuccessful reperfusion; p0.05), and of neutrophil adhesion (6.2+/-5.7 to 2.7+/-3.0 vs. 4.1+/-3.8 to 3.5+/-4.0 in unsuccessful reperfusion; p0.05) during thrombolysis. Systemic thrombolysis in acute myocardial infarction is accompanied by a reduction in neutrophil adhesion and activation dependent on thrombolytic success.
- Subjects :
- Male
medicine.medical_specialty
Neutrophil adhesion
Neutrophils
Neutrophile
medicine.medical_treatment
Myocardial Infarction
Myocardial Reperfusion
Neutrophil Activation
Fibrinolytic Agents
Internal medicine
Cell Adhesion
medicine
Humans
Myocardial infarction
Aged
Chemotherapy
Polymorphonuclear neutrophil
business.industry
Hematology
Thrombolysis
Adhesion
Middle Aged
medicine.disease
Recombinant Proteins
Tissue Plasminogen Activator
Acute Disease
Immunology
Cardiology
Female
business
Plasminogen activator
Subjects
Details
- ISSN :
- 00493848
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Thrombosis Research
- Accession number :
- edsair.doi.dedup.....f0b372a36f9627793377d91c85464e49