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The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues
- Source :
- Frontiers in Physiology, Vol 8 (2017), Frontiers in Physiology
- Publication Year :
- 2017
- Publisher :
- Frontiers Media S.A., 2017.
-
Abstract
- PGC-1α coactivator plays a decisive role in the maintenance of lipid balance via engagement in numerous metabolic processes (i.e., Krebs cycle, β-oxidation, oxidative phosphorylation and electron transport chain). It constitutes a link between fatty acids import and their complete oxidation or conversion into bioactive fractions through the coordination of both the expression and subcellular relocation of the proteins involved in fatty acid transmembrane movement. Studies on cell lines and/or animal models highlighted the existence of an upregulation of the total and mitochondrial FAT/CD36, FABPpm and FATPs content in skeletal muscle in response to PGC-1α stimulation. On the other hand, the association between PGC-1α level or activity and the fatty acids transport in the heart and adipocytes is still elusive. So far, the effects of PGC-1α on the total and sarcolemmal expression of FAT/CD36, FATP1, and FABPpm in cardiomyocytes have been shown to vary in relation to the type of PPAR that was coactivated. In brown adipose tissue (BAT) PGC-1α knockdown was linked with a decreased level of lipid metabolizing enzymes and fatty acid transporters (FAT/CD36, FABP3), whereas the results obtained for white adipose tissue (WAT) remain contradictory. Furthermore, dysregulation in lipid turnover is often associated with insulin intolerance, which suggests the coactivator's potential role as a therapeutic target.
- Subjects :
- 0301 basic medicine
Physiology
CD36
Peroxisome proliferator-activated receptor
PGC-1α
Review
White adipose tissue
Oxidative phosphorylation
lcsh:Physiology
03 medical and health sciences
0302 clinical medicine
insulin sensitive tissues
FATPs
Physiology (medical)
Brown adipose tissue
lipid metabolism
medicine
chemistry.chemical_classification
biology
lcsh:QP1-981
FAT/CD36
Fatty acid
Lipid metabolism
Citric acid cycle
030104 developmental biology
medicine.anatomical_structure
FABPpm
chemistry
Biochemistry
030220 oncology & carcinogenesis
biology.protein
Subjects
Details
- Language :
- English
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology
- Accession number :
- edsair.doi.dedup.....f0a5969129294bd37b1b6f3d06c765a5