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Cancer incidence and causes of death among total hip replacement patients: a review based on Nordic cohorts with a special emphasis on metal-on-metal bearings
- Source :
- Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine. 220(2)
- Publication Year :
- 2006
-
Abstract
- All patients with total hip arthroplasty (THA) are exposed to soluble or particulate forms of Co and Cr. Adverse effects of these wear products are not known. Data from Nordic registries is used to estimate adverse effects on a large scale, based mostly on metal-on-polyethylene bearings. Cancer incidence was in line with the general population when the patients were operated on for all indications and significantly decreased when the indication was primary osteoarthritis. Stomach cancer and colorectal cancers were significantly reduced and prostate cancer and skin melanoma significantly increased. There was no significant excess of cancer in target organs, i.e. liver, kidney, or haematopoietic cancers. THA patients had reduced mortality and extended life expectancy compared with standard Nordic populations. All-site cancer incidence of the first-generation metal-on-metal McKee-Farrar patients operated on for primary osteoarthritis was in line with the general population after follow-up for up to 28 years. General mortality of these patients was also reduced and they also had an extended life expectancy. Temporary increases in haematopoietic cancers at different follow-up periods were seen in some cohorts. This malignancy deserves a special record linkage monitoring while large numbers of young patients are provided with the second generation of metal-on-metal prostheses.
- Subjects :
- medicine.medical_specialty
Arthroplasty, Replacement, Hip
Denmark
Population
Biocompatible Materials
Risk Assessment
Cohort Studies
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Risk Factors
Internal medicine
Cause of Death
Neoplasms
medicine
Humans
Registries
Adverse effect
Stomach cancer
education
Finland
Sweden
030222 orthopedics
education.field_of_study
business.industry
Norway
Mechanical Engineering
Incidence
Cancer
General Medicine
medicine.disease
3. Good health
Surgery
Cancer incidence
Metals
030220 oncology & carcinogenesis
Life expectancy
Hip Prosthesis
business
Total hip arthroplasty
Subjects
Details
- ISSN :
- 09544119
- Volume :
- 220
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
- Accession number :
- edsair.doi.dedup.....f097a67ddddfcc0821501d00c26c7a68