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Anxiolytic-like effect of linezolid in experimental mouse models of anxiety
- Source :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry. 40:47-53
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Linezolid, an oxazolidinone class antibiotic is a reversible and nonselective inhibitor of monoamine oxidase (MAO) enzyme, mainly for MAO-A subtype. Its antidepressant-like effect has been previously demonstrated in the rodent models of depression. MAO-A enzyme has been shown to play a role in the pathophysiology of anxiety disorders and inhibition of MAO-A in the brain could be used to treat anxiety disorders. Thus, the objective of this study was to investigate the putative anxiolytic effects of linezolid in rodent models of anxiety. Mice were acutely injected with linezolid (5-40 mg/kg, i.p.), diazepam (2 mg/kg, i.p.) and moclobemide (10 mg/kg., i.p.). Linezolid (20 and 40 mg/kg), diazepam and moclobemide significantly (p
- Subjects :
- Male
Elevated plus maze
Monoamine Oxidase Inhibitors
Monoamine oxidase
medicine.drug_class
Emotions
Anxiety
Motor Activity
Pharmacology
Anxiolytic
Mice
chemistry.chemical_compound
Acetamides
Moclobemide
Animals
Medicine
heterocyclic compounds
Oxazolidinones
Biological Psychiatry
5-HT receptor
Behavior, Animal
business.industry
Linezolid
Disease Models, Animal
Anti-Anxiety Agents
chemistry
Analysis of variance
business
Diazepam
medicine.drug
Subjects
Details
- ISSN :
- 02785846
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....f0907895c9d6947de30a47562469becb