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Association of Genetic Variants in IGF2-Related Genes With Risk of Metabolic Syndrome in the Chinese Han Population
- Source :
- Frontiers in Endocrinology, Vol 12 (2021), Frontiers in Endocrinology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- AimsTo explore associations between polymorphisms of IGF2-related genes including H19, IGF2, IGF2BP2 and IGF2R and Metabolic syndrome (MetS) susceptibility in the Chinese Han population.Methods66 subjects with MetS and 257 control subjects were collected for inclusion in a case-control study. PCR-RFLP was used to investigate polymorphisms in the H19, IGF2, IGF2BP2 and IGF2R genes. Elisa was used to detect the serum IGF2 concentrations.ResultsFemales carrying the GG and AG genotypes of rs680 (IGF2) exhibited a lower risk of MetS, compared with those harboring AA (adjusted OR = 0.388, p = 0.027), while GG and AG genotypes were associated with lower fasting glucose and HbA1c. In males, the Waist-to-Hip Ratio (WHR) and the level of TG were significantly higher in GG and AG genotypes than in the AA genotype of rs680 in IGF2. Levels of HDL-c were lower in men with GG and AG genotypes compared with those carrying the AA genotype. Serum IGF2 concentrations did not change among different genotypes. Finally, multifactor dimensionality reduction (MDR) analysis identified interactions between four polymorphisms: rs3741279 (H19), rs680 (IGF2), rs1470579 (IGF2BP2) and rs629849 (IGF2R).ConclusionsOur study suggests that IGF2-related genes including H19, IGF2, IGF2BP2 and IGF2R genes may play pivotal roles in the development of MetS.
- Subjects :
- Male
0301 basic medicine
China
animal structures
Genotype
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Single-nucleotide polymorphism
Biology
Lower risk
Polymorphism, Single Nucleotide
Receptor, IGF Type 2
metabolic syndrome
Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
single nucleotide polymorphisms
Endocrinology
0302 clinical medicine
Chinese han population
Insulin-Like Growth Factor II
medicine
Humans
Genetic Predisposition to Disease
Gene
Original Research
Aged
Genetics
IGF2BP2
Multifactor dimensionality reduction
H19
Insulin-like growth factor 2 receptor
IGF2
RNA-Binding Proteins
Middle Aged
Prognosis
medicine.disease
RC648-665
female genital diseases and pregnancy complications
030104 developmental biology
Case-Control Studies
030220 oncology & carcinogenesis
Female
RNA, Long Noncoding
Metabolic syndrome
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Endocrinology
- Accession number :
- edsair.doi.dedup.....f07e4ea9aedc09c72a619d4fcfcfb8fc