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Effects of diabetes and CETP expression on diet-induced atherosclerosis in LDL receptor-deficient mice
- Source :
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 113(1)
- Publication Year :
- 2005
-
Abstract
- The role of CETP expression and diabetes in atherogenesis was investigated in mice with heterozygous disruption of the LDL receptor gene (LDLR1). LDLR1 mice with and without CETP expression were treated with streptozotocin (STZ) and maintained on a standard diet for one month before switching to an atherogenic diet for an additional month. STZ-sensitive mice had approximately 2.5-fold higher glycemia and 7.5- to 8.0-fold higher cholesterolemia. Factorial analysis of variance showed no significant effect of diabetes, CETP or diabetes-CETP interaction on the size of the atherosclerotic lesions. CETP expression in non-diabetic mice resulted in a 50% reduction in the area of the atherosclerotic lesions. Multiple regression analysis showed a positive and independent atherogenic effect of triglyceridemia in LDLR1 mice and of cholesterolemia in diabetic mice. Logistic analysis showed that elevated plasma cholesterol level significantly increased the risk of developing large lesion size (>75th percentile). In conclusion, CETP expression did not alter the lesion formation in response to diabetes, although it may be protective in the euglycemic state; the triglyceride level was an independent risk factor for LDL receptor-deficient mice but not for CETP-expressing mice; and elevated plasma cholesterol levels increased the risk of developing large atherosclerotic lesions, independently of CETP and diabetes.
- Subjects :
- Microbiology (medical)
Blood Glucose
medicine.medical_specialty
Ratón
Arteriosclerosis
Pathology and Forensic Medicine
Diabetes Mellitus, Experimental
Lesion
Mice
Diabetes mellitus
Internal medicine
Cholesterylester transfer protein
medicine
Immunology and Allergy
Animals
Risk factor
Receptor
Glycoproteins
biology
business.industry
General Medicine
medicine.disease
Streptozotocin
Lipids
Cholesterol Ester Transfer Proteins
carbohydrates (lipids)
Endocrinology
Receptors, LDL
LDL receptor
biology.protein
Diet, Atherogenic
Regression Analysis
lipids (amino acids, peptides, and proteins)
medicine.symptom
business
Carrier Proteins
Diabetic Angiopathies
medicine.drug
Subjects
Details
- ISSN :
- 09034641
- Volume :
- 113
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- Accession number :
- edsair.doi.dedup.....f0707b8199b3e7b79a9acb84decf5500