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Impact of self-designed Ningxin Anshen Decoction on the resting-state network functional connectivity in patients with mild to moderate generalized anxiety disorders
- Source :
- Annals of palliative medicine. 10(2)
- Publication Year :
- 2020
-
Abstract
- Background Generalized anxiety disorder (GAD) is a persistent chronic excessive anxiety that is hard to control. Our previous study indicated that self-designed Ningxin Anshen Formula (NXAS) was effective to treat mild to moderate GAD patients. This study is a randomized controlled clinical trial and aimed to investigate the imapct of self-designed NXAS on the resting-state functional connectivity (rsFC) in patients with mild to moderate GAD and explore the potential mechanisms. Methods A total of 61 patients diagnosed with mild to moderate GAD were recruited and divided into two groups randomly: NXAS group (n=31) and placebo group (n=30). Before and after treatment, the rsFC was examined by resting-state functional MRI (rs-fMRI), the anxiety was assessed with HAMA, and the independent component analysis (ICA) was used to analyze the resting-state functional connectivity (rsFC). The correlation between HAMA score and abnormal rsFC was further evaluated. Results The default mode network (DMN) showed evident rsFC interaction in the PCUN in both groups before and after therapy. The salience network (SN) showed obvious rsFC interaction in the bilateral gyrus frontalis inferiors and bilateral gyri temporalis superiors before and after therapy. In the NXAS group, the rsFC interction reduced significantly in the left gyrus frontalis inferior, but remained unchanged in the right gyrus frontalis inferior and bilateral gyri temporalis superiors after therapy. In the control group, the rsFC interaction increased dramatically after treatment. In addition, the abnormal rsFC had no relationship with HAMA score. Conclusions The self-designed NXAS can increase the rsFC in the PUCN on DMN and reduce rsFC in the orbIFG.L on SN to exert anti-anxiety effect.
- Subjects :
- medicine.medical_specialty
Generalized anxiety disorder
Audiology
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Gyrus
Medicine
Humans
0501 psychology and cognitive sciences
In patient
Default mode network
Advanced and Specialized Nursing
Brain Mapping
Resting state fMRI
business.industry
Functional connectivity
05 social sciences
Brain
medicine.disease
Anxiety Disorders
Magnetic Resonance Imaging
Anesthesiology and Pain Medicine
Generalized anxiety
medicine.anatomical_structure
Anxiety
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22245839
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Annals of palliative medicine
- Accession number :
- edsair.doi.dedup.....f06c7b9e2f9169075fb27d9d4c37a68a