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Risk of chronic kidney disease in young adults with impaired glucose tolerance/impaired fasting glucose : a retrospective cohort study using electronic primary care records
- Source :
- BMC Nephrology, BMC Nephrology, Vol 19, Iss 1, Pp 1-8 (2018)
- Publication Year :
- 2018
- Publisher :
- BioMed Central Ltd., 2018.
-
Abstract
- Background The risk of chronic kidney disease (CKD) is known to be elevated in patients with diabetes mellitus but the risk of young adults aged 18 to 40 years with impaired glucose tolerance/impaired fasting glucose (IGT/IFG) developing CKD is not well characterised. Furthermore, progression of IGT/IFG to diabetes and subsequent CKD development is not well understood. Methods A retrospective cohort study was undertaken using The Health Improvement Network (THIN) database, a large dataset of electronic patient records. THIN database is jointly managed by IMS Health Real World Evidence Solution (http://www.epic-uk.org/index.html) and In Practice System (InPs). Cases were aged 18 to 40, with a diagnosis of IGT/IFG and registered at a practice contributing to THIN between 2000 and 2015. The study population consisted of 40,092 patients, including 21,454 (53.5%) female and 18,638 (46.5%) male. The median follow-up was approximately 2 years. The outcome was a diagnosis of CKD determined from either clinical coding or laboratory results. For the primary analysis the unadjusted and adjusted relative risk of CKD in IGT/IFG was compared to age, sex and practice matched controls with normoglycaemia. For the secondary analysis we compared the incidence of CKD before to after a diagnosis of type 2 diabetes (T2DM) in the IGT/IFG study cohort. Results The Incidence Rate Ratio (IRR) for CKD for IGT/IFG compared to normoglycaemia was 4.0 [95% confidence interval (CI), 3.2 to 5.1, P
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
endocrine system diseases
030209 endocrinology & metabolism
Type 2 diabetes
lcsh:RC870-923
Rate ratio
The Health Improvement Network (THIN) database
Incidence rate ratio (IRR)
Cohort Studies
Impaired glucose tolerance
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Chronic kidney disease
Internal medicine
Diabetes mellitus
Glucose Intolerance
medicine
Electronic Health Records
Humans
030212 general & internal medicine
Renal Insufficiency, Chronic
Retrospective Studies
Type 2 diabetes (T2DM)
Primary Health Care
business.industry
Read code
nutritional and metabolic diseases
Retrospective cohort study
Fasting
Glucose Tolerance Test
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
Impaired fasting glucose
United Kingdom
Diabetes Mellitus, Type 2
Nephrology
Cohort
Female
business
Research Article
Follow-Up Studies
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 14712369
- Database :
- OpenAIRE
- Journal :
- BMC Nephrology, BMC Nephrology, Vol 19, Iss 1, Pp 1-8 (2018)
- Accession number :
- edsair.doi.dedup.....f03c3f557d31c91196992a6c190386e9