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Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development
- Source :
- Biology Open, Biology Open, 1(8), 693-704. Company of Biologists Ltd, Biology Open, Vol 1, Iss 8, Pp 693-704 (2012), Biology Open; Vol 1, Biology open, Vol. 1, no.8, p. 693-704 (2012)
- Publication Year :
- 2012
- Publisher :
- The Company of Biologists, 2012.
-
Abstract
- Summary Meso-diencephalic dopaminergic (mdDA) neurons are critical for motor control and cognitive functioning and their loss or dysfunction is associated with disorders such as Parkinson's disease (PD), schizophrenia and addiction. However, relatively little is known about the molecular mechanisms underlying mdDA neuron development and maintenance. Here, we determined the spatiotemporal map of genes involved in the development of mdDA neurons to gain further insight into their molecular programming. Genome-wide gene expression profiles of the developing ventral mesencephalon (VM) were compared at different developmental stages leading to the identification of novel regulatory roles of neuronal signaling through nicotinic acthylcholine receptors (Chrna6 and Chrnb3 subunits) and the identification of novel transcription factors (Oc2 and 3) involved in the generation of the mdDA neuronal field. We show here that Pitx3, in cooperation with Nurr1, is the critical component in the activation of the Chrna6 and Chrnb3 subunits in mdDA neurons. Furthermore, we provide evidence of two divergent regulatory pathways resulting in the expression of Chrna6 and Chrnb3 respectively.
- Subjects :
- QH301-705.5
Neuronal
Science
Pitx3
Development
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Midbrain
03 medical and health sciences
0302 clinical medicine
Gene expression
medicine
Biology (General)
Transcription factor
Gene
030304 developmental biology
0303 health sciences
biology
CHRNA6
Dopaminergic
Onecut
Nurr1
medicine.anatomical_structure
Nicotinic agonist
nervous system
biology.protein
Neuron
General Agricultural and Biological Sciences
Neuroscience
030217 neurology & neurosurgery
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20466390
- Volume :
- 1
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Biology Open
- Accession number :
- edsair.doi.dedup.....f03b436bc939dfa8b39ba4d02a8ceff2