Back to Search
Start Over
Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity
- Source :
- Toxicology Letters. 334:36-43
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Cisplatin is a widely used chemotherapeutic agent. However, it is causing nephrotoxic side effects including a reduced glomerular filtration rate and acute kidney injury. Although kidneys can recover to an extent from the treatment, long-term damage is possible. While a lot of research is focusing on short-term effects, little is known about adverse metabolic effects in the process of recovery. In this study, male Han Wistar rats were dosed with a single intraperitoneal injection of 3 mg/kg cisplatin. Urine and kidney samples were harvested 3, 8 and 26 days after administration. Tubular injury was demonstrated through urinary biomarkers. Complementing this, mass spectrometry imaging gives insight on molecular alterations on a spatial level, thus making it well suited to analyze short- and long-term disturbances. Various metabolic pathways seem to be affected, as changes in a wide range of metabolites were observed between treated and control animals. Besides previously reported early changes in kidney metabolism, unprecedented long-term effects were detected including deviation in nucleotides, antioxidants, and phospholipids. Copyright © 2020 Elsevier B.V. All rights reserved.
- Subjects :
- Male
0301 basic medicine
Time Factors
medicine.medical_treatment
Intraperitoneal injection
Renal function
Antineoplastic Agents
Urine
Pharmacology
Kidney
Toxicology
Antioxidants
Nephrotoxicity
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Rats, Wistar
Cisplatin
business.industry
Acute kidney injury
Kidney metabolism
General Medicine
medicine.disease
Kidney Tubules
030104 developmental biology
medicine.anatomical_structure
Energy Metabolism
business
Biomarkers
Injections, Intraperitoneal
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 03784274
- Volume :
- 334
- Database :
- OpenAIRE
- Journal :
- Toxicology Letters
- Accession number :
- edsair.doi.dedup.....f02f38249b005b68154bc2db93418bdc