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Optimized Reference Intervals for Plasma Free Metanephrines in Patients With CKD
- Source :
- American Journal of Kidney Diseases, 72, 907-909, BASE-Bielefeld Academic Search Engine, American Journal of Kidney Diseases, 72, 6, pp. 907-909
- Publication Year :
- 2018
-
Abstract
- To the Editor: The diagnostic work-up of pheochromocytoma/paraganglioma (PPGL) among patients with chronic kidney disease (CKD) is a clinical challenge. Impaired renal elimination of catecholamines and their metabolites confounds urinary tests, while increased plasma concentrations of free metanephrines in patients with CKD also complicate interpretation of plasma tests.1, 2, 3 We therefore aimed to establish optimal reference intervals for plasma free metanephrines and 3-methoxytyramine in patients with CKD stages 3 and 4 or receiving hemodialysis (HD). This prospective multicenter study included 234 patients (79 CKD3, 48 CKD4, and 107 receiving HD) and an aged-matched reference population of 173 individuals (Table 1; Item S1). Measurements of plasma free normetanephrine, metanephrine, and 3-methoxytyramine were performed using liquid chromatography–tandem mass spectrometry (LC-MS/MS).4
- Subjects :
- Male
medicine.medical_specialty
Urinary system
medicine.medical_treatment
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
10265 Clinic for Endocrinology and Diabetology
Adrenal Gland Neoplasms
Urology
610 Medicine & health
030209 endocrinology & metabolism
Pheochromocytoma
030204 cardiovascular system & hematology
Risk Assessment
Sensitivity and Specificity
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Reference Values
medicine
Humans
Prospective Studies
Renal Insufficiency, Chronic
Prospective cohort study
Metanephrine
Aged
2727 Nephrology
business.industry
Metanephrines
Middle Aged
medicine.disease
Renal Elimination
chemistry
Nephrology
Case-Control Studies
Disease Progression
Female
Hemodialysis
business
Biomarkers
Kidney disease
Subjects
Details
- ISSN :
- 02726386
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- American Journal of Kidney Diseases
- Accession number :
- edsair.doi.dedup.....f02c6e71e1a9f82afad64666a9af41cd