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Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment
- Source :
- Advanced Science
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- The blood brain barrier is the main obstacle to delivering diagnostic and therapeutic agents to the diseased sites of brain. It is still of great challenge for the combined use of focused ultrasound (FUS) and theranostic nanotechnology to achieve noninvasive and localized delivery of chemotherapeutic drugs into orthotopic brain tumor. In this work, a unique theranostic nanoplatform for highly efficient photoacoustic imaging‐guided chemotherapy of brain tumor both in vitro and in vivo, which is based on the utilization of hollow mesoporous organosilica nanoparticles (HMONs) to integrate ultrasmall Cu2− xSe particles on the surface and doxorubicin inside the hollow interior, is synthesized. The developed multifunctional theranostic nanosystems exhibit tumor‐triggered programmed destruction due to the reducing microenvironment‐responsive cleavage of disulfide bonds that are incorporated into the framework of HMONs and linked between HMONs and Cu2− xSe, resulting in tumor‐specific biodegradation and on‐demand drug‐releasing behavior. Such tumor microenvironment‐responsive biodegradable and biocompatible theranostic nanosystems in combination with FUS provide a promising delivery nanoplatform with high performance for orthotopic brain tumor imaging and therapy.
- Subjects :
- theranostic
General Chemical Engineering
Combined use
Brain tumor
General Physics and Astronomy
Medicine (miscellaneous)
blood brain barrier
02 engineering and technology
010402 general chemistry
Blood–brain barrier
01 natural sciences
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Focused ultrasound
medicine
General Materials Science
Doxorubicin
Full Paper
Chemistry
General Engineering
Full Papers
021001 nanoscience & nanotechnology
Biocompatible material
medicine.disease
0104 chemical sciences
Mesoporous organosilica
medicine.anatomical_structure
focused ultrasound
biodegradable
Chemotherapeutic drugs
0210 nano-technology
brain tumor
Biomedical engineering
medicine.drug
Subjects
Details
- ISSN :
- 21983844
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Advanced Science
- Accession number :
- edsair.doi.dedup.....f020a1f53c9cef2d09479093331b95e5