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In vitro and in vivo anti-Listeria effect of Succinoglycan Riclin through regulating MAPK/IL-6 axis and metabolic profiling
- Source :
- International Journal of Biological Macromolecules. 150:802-813
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Infectious diseases such as Listeria monocytogenes infection pose a great threat to the health of human beings and the development of livestock and poultry farming. Currently the treatment of Listeria infection mainly relies on antibiotics, which may result in excessive antibiotic residues in livestock and poultry products, as well as causing an increase in the occurrence of zoonotic diseases. Here, we demonstrate that Succinoglycan Riclin promoted the clearance of Listeria in the in vitro and in vivo infection model. The expression and secretion of inflammatory cytokines including IL-6 and IL-1β were significantly increased after Riclin treatment upon infection. The protective effect of Riclin was mainly through activating MAPK/IL-6 axis. HO-1/IL-1β signaling pathway was less important in this process. Moreover, Riclin caused significant metabolic changes including pathways involved in glycolysis, protein synthesis and oxidative stress during Listeria infection. These results suggest a potential use of Succinoglycan Riclin as non-antibiotic preventive and therapeutic anti-microbial agent in livestock and poultry farming and human diseases.
- Subjects :
- MAPK/ERK pathway
MAP Kinase Signaling System
medicine.drug_class
Antibiotics
02 engineering and technology
medicine.disease_cause
Listeria infection
Biochemistry
Proinflammatory cytokine
Microbiology
Mice
03 medical and health sciences
Listeria monocytogenes
Structural Biology
In vivo
medicine
Animals
Listeriosis
Secretion
Extracellular Signal-Regulated MAP Kinases
Molecular Biology
030304 developmental biology
0303 health sciences
biology
Interleukin-6
Polysaccharides, Bacterial
General Medicine
021001 nanoscience & nanotechnology
biology.organism_classification
medicine.disease
Anti-Bacterial Agents
RAW 264.7 Cells
Listeria
Female
0210 nano-technology
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 150
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....f015bd5115656e45ecda46f43fd16810