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Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women
- Source :
- The Journal of nutrition. 140(9)
- Publication Year :
- 2010
-
Abstract
- In premenopausal women, elevated C-reactive protein (CRP) concentrations have been associated with an increased risk of negative reproductive outcomes. Whole grain consumption has been associated with lower CRP concentrations in older women; however, less is known about this relationship in younger women. We investigated whether whole grain intake was associated with serum high sensitivity CRP (hs-CRP) concentrations in young women. BioCycle was a prospective cohort study conducted at the University of Buffalo from 2005 to 2007, which followed 259 healthy women aged 18–44 y for le 2 menstrual cycles. hs-CRP concentrations were measured longitudinally le 8 times/cycle with visits standardized to menstrual cycle phase. Whole grain intake was estimated by 24-h recalls le 4 times/cycle. Servings were defined as 16 g or 125 mL of a 100% whole grain food. Whole grain intake was inversely associated with hs-CRP concentrations after adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP concentrations (P = 0.02) and consumers of ge 1 serving/d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers. Women who consumed ge 1 serving/d of whole grain had a lower probability of having moderate (P = 0.008) or elevated (P = 0.001) hs-CRP according to the AHA criteria compared with nonconsumers. Given that elevated concentrations of hs-CRP have been linked to adverse reproductive outcomes and pregnancy complications, interventions targeting whole grain consumption may have the potential to improve health status among young women.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
media_common.quotation_subject
New York
Medicine (miscellaneous)
Diet Surveys
Cohort Studies
Young Adult
Animal science
Internal medicine
medicine
Humans
Nutritional Epidemiology
Young adult
Prospective cohort study
Menstrual cycle
media_common
Pregnancy
Nutrition and Dietetics
biology
business.industry
C-reactive protein
Feeding Behavior
medicine.disease
Diet
Menstrual cycle phase
Menopause
Endocrinology
C-Reactive Protein
Premenopause
biology.protein
Female
business
Edible Grain
Food Analysis
Cohort study
Subjects
Details
- ISSN :
- 15416100
- Volume :
- 140
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The Journal of nutrition
- Accession number :
- edsair.doi.dedup.....f011676f05b762a5eb2764aa775d481d