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Failure of a chloroquine chemoprophylaxis program to adequately prevent malaria during pregnancy in Koupéla District, Burkina Faso
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 36(11)
- Publication Year :
- 2002
-
Abstract
- In West Africa, administration of chloroquine chemoprophylaxis during pregnancy is common, but little is known about its impact on Plasmodium falciparum infection during pregnancy. Therefore, cross-sectional studies in antenatal care clinics (ANCs) and delivery units (DUs) were conducted in Koupela District, Burkina Faso. Chloroquine chemoprophylaxis was reported by 69% of 597 pregnant women at ANCs and by 93% of 853 women in DUs. P. falciparum peripheral parasitemia was identified in 29% of women at both ANCs and DUs. Placental parasitemia was identified in 22% of delivering women and was strongly associated with low birth weight (LBW) (risk ratio (RR), 1.7; 95% confidence interval (CI), 1.2-2.4) and prematurity (RR, 2.9; 95% CI, 1.6-5.4). In multivariate analysis, use of chemoprophylaxis was not associated with a reduction in the prevalence of placental parasitemia, LBW, or prematurity. Despite the high reported chloroquine che- moprophylaxis coverage, peripheral and placental malaria rates remain high and are associated with known adverse outcomes during pregnancy, including maternal anemia, prematurity, and LBW. Alternative prevention strategies, such as use of insecticide-treated mosquito nets and intermittent preventive treatment with more- effective antimalarials, are needed.
- Subjects :
- Microbiology (medical)
Adult
medicine.medical_specialty
Insecticides
Adolescent
Population
Parasitemia
Prenatal care
Disease Vectors
Chemoprevention
Antimalarials
Chloroquine
Pregnancy
parasitic diseases
Burkina Faso
medicine
Animals
Humans
Malaria, Falciparum
education
education.field_of_study
business.industry
Obstetrics
Infant, Newborn
Infant, Low Birth Weight
medicine.disease
Mefloquine
Low birth weight
Infectious Diseases
Cross-Sectional Studies
Culicidae
Treatment Outcome
Pregnancy Complications, Parasitic
Chemoprophylaxis
Female
medicine.symptom
business
Malaria
medicine.drug
Subjects
Details
- ISSN :
- 15376591
- Volume :
- 36
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....f010e3f5bd1ee9082eaaafdd521ec994