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The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203
- Source :
- Molecules, Vol 22, Iss 7, p 1152 (2017), Molecules; Volume 22; Issue 7; Pages: 1152, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- The ability of two newly developed oximes (K305, K307) to protect tabun-poisoned rats from tabun-induced inhibition of brain acetylcholinesterase, acute neurotoxic signs and symptoms and brain damage was compared with that of the oxime K203 and trimedoxime. The reactivating and neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose were evaluated. The reactivating efficacy of a newly developed oxime K305 is lower compared to the reactivating efficacy of the oxime K203 and trimedoxime while the ability of the oxime K307 to reactivate tabun-inhibited acetylcholinesterase (AChE) in the brain roughly corresponds to the reactivating efficacy of the oxime K203 and it is slightly lower compared to trimedoxime. In addition, only one newly developed oxime (K307) combined with atropine was able to markedly decrease tabun-induced neurotoxicity although it did not eliminate all tabun-induced acute neurotoxic signs and symptoms. These results correspond to the histopathological evaluation of tabun-induced brain damage. Therefore, the newly developed oximes are not suitable for the replacement of commonly used oximes (especially trimedoxime) in the treatment of acute tabun poisonings.
- Subjects :
- Atropine
Male
0301 basic medicine
Cholinesterase Reactivators
Pharmaceutical Science
Pyridinium Compounds
Pharmacology
Analytical Chemistry
chemistry.chemical_compound
Organophosphate Poisoning
0302 clinical medicine
Drug Discovery
neurotoxicity
Chemical Warfare Agents
Brain
acetylcholinesterase
Oxime
Acetylcholinesterase
Organophosphates
Neuroprotective Agents
Chemistry (miscellaneous)
histopathology
Molecular Medicine
Neurotoxicity Syndromes
Trimedoxime
medicine.symptom
medicine.drug
oximes
Brain damage
Neuroprotection
Article
lcsh:QD241-441
03 medical and health sciences
functional observational battery
lcsh:Organic chemistry
medicine
Animals
Humans
Rats, Wistar
Physical and Theoretical Chemistry
Tabun
tabun
rats
Organic Chemistry
Neurotoxicity
medicine.disease
030104 developmental biology
chemistry
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 22
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....f007016ad1f1426d687a018c69bf01fb