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Preoperative FDG-PET-Scan in Patients with Resectable Colorectal Liver Metastases Does Not Improve Overall Survival: A Retrospective Analyses Stratified by Clinical Risk Score
- Source :
- Digestive Surgery, 30(4-6), 451-458. Karger
- Publication Year :
- 2013
- Publisher :
- S. Karger AG, 2013.
-
Abstract
- Background: The aim of this study was to determine whether selection with fluorine-18-deoxyglucose positron emission tomography (FDG-PET) imaging would result in an improved outcome in surgically treated patients with curative resection of colorectal liver metastases (CRLM), stratified by the clinical risk score (CRS) of Fong et al. [Ann Surg 1999;230:309-318]. Patients and Methods: Between January 2000 and December 2009, all patients who underwent resection for CRLM from two different university teaching hospitals in the Netherlands were analysed. Patients were stratified by the CRS. Results: In total 613 patients were eligible for analysis. There was no statistical difference in median disease-free survival (DFS) between patients with and without an FDG-PET scan in both low CRS [17 months (95% CI 12-22) vs. 14 months (95% CI 11-17), p = 0.332] and high CRS [14 months (95% CI 7-21) vs. 9 months (95% CI 8-10), p = 0.073]. There was no statistical difference in median overall survival (OS) between patients with and without an FDG-PET scan in both low CRS [64 months (95% CI 54-74) vs. 54 months (95% CI 42-66), p = 0.663] and high CRS [39 months (95% CI 23-55) vs. 41 months (95% CI 34-48), p = 0.903]. Conclusion: The present study could not demonstrate that patients selected by an FDG-PET scan before liver resection, and stratified by CRS, have an improvement in DFS or OS.
- Subjects :
- Male
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
Disease-Free Survival
Fluorodeoxyglucose F18
Antineoplastic Combined Chemotherapy Protocols
Overall survival
medicine
Hepatectomy
Humans
Survival rate
Aged
Neoplasm Staging
Retrospective Studies
Chemotherapy
medicine.diagnostic_test
business.industry
Liver Neoplasms
Gastroenterology
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Survival Rate
Treatment Outcome
Chemotherapy, Adjuvant
Positron emission tomography
Lymphatic Metastasis
Positron-Emission Tomography
Female
Surgery
Radiology
Colorectal Neoplasms
business
Clinical risk factor
Follow-Up Studies
Subjects
Details
- ISSN :
- 14219883 and 02534886
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Digestive Surgery
- Accession number :
- edsair.doi.dedup.....f004bef17b08f13dbf80cc01d81e68c4