Effects of off-pump versus on-pump coronary artery bypass grafting: Apoptosis, ınflammation, and oxidative stress

Background: It has been suggested that off-pump coronaryartery bypass grafting (CABG) surgery reduces myocardialischemia-reperfusion injury, postoperative systemicinflammatory response, and oxidative stress. The aim of thisstudy was to measure serum malondialdehyde (MDA), highsensitivityC-reactive protein (hs-CRP), M30, and M65 levelsand to investigate the relationship between M30 levels andoxidative stress and inflammation in patients undergoing onandoff-pump CABG surgery.Methods: Fifty patients were randomly assigned to onpumpor off-pump CABG surgery (25 patients off-pump and25 on-pump CABG surgery), and blood samples were collectedprior to surgery, and 30 minutes, 60 minutes, 6 hours,and 24 hours after CABG surgery.Results: Compared to the on-pump group, serum MDAlevels at 30 minutes, 60 minutes, 6 hours, and 24 hours afterthe CABG surgery were significantly lower in the off-pumpgroup (P = .001, P = .001, P = .001, and P = .001, respectively).Serum M30 levels were found to be elevated in both groups,returning to baseline at 24 hours. When compared to baseline,the hs-CRP level reached its peak at 24 hours at 13.28 ±5.32 mg/dL in the on-pump group, and 15.44 ± 4.02 mg/dLin the off-pump group.Conclusion: CABG surgery is associated with an increasein inflammatory markers and serum M30 levels, indicatingepithelial/endothelial apoptosis in the early period.