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Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery for hepatocellular carcinoma
- Source :
- Internal medicine (Tokyo, Japan). 46(7)
- Publication Year :
- 2007
-
Abstract
- We describe a 64-year-old man with decompensated hepatitis B virus (HBV)-related cirrhosis who became resistant to lamivudine. He was started on adefovir at 10 mg daily while continuing lamivudine therapy. Several months later, his liver function improved and subsequently his ascites disappeared. The serum HBV-DNA level became undetectable 11 months later. Twenty months after the start of additional treatment with adefovir, one hepatocellular carcinoma (HCC) was detected, and the patient underwent a successful hepatectomy. Our findings suggest that the addition of adefovir to ongoing lamivudine therapy is useful for improving liver function in patients with decompensated lamivudine-resistant HBV-related cirrhosis, allowing surgery for HCC.
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Carcinoma, Hepatocellular
medicine.medical_treatment
Organophosphonates
medicine.disease_cause
Risk Assessment
Severity of Illness Index
Hepatitis B, Chronic
Liver Function Tests
Ascites
Drug Resistance, Viral
Internal Medicine
medicine
Adefovir
Hepatectomy
Humans
Hepatitis B virus
business.industry
Adenine
Liver Neoplasms
virus diseases
Lamivudine
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
digestive system diseases
Surgery
Cell Transformation, Neoplastic
Treatment Outcome
Hepatocellular carcinoma
Disease Progression
Liver function
medicine.symptom
business
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 13497235
- Volume :
- 46
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Internal medicine (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....efedf3cc06eddf324ecead3cbc978057