Back to Search
Start Over
Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using directâacting antivirals
- Source :
- Hepatology Research. 51:758-766
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- AIM Direct-acting antivirals have revolutionized hepatitis C virus (HCV) therapy by providing a high sustained virological response (SVR) rate and subsequent favorable lipid increases. Proprotein convertase subtilisin-kexin like-9 (PCSK9) plays an important role in regulating quantitative lipid levels. This study examined the interactions between quantitative PCSK9 and lipid changes, as well as qualitative lipid changes in terms of lectin-like oxidized low-density lipoprotein (LDL) receptor-1 ligand containing apolipoprotein B (LAB) and high-density lipoprotein (HDL) cholesterol uptake capacity (HDL-CUC). METHODS Patients with chronic HCV infection (N = 231) who achieved an SVR by direct-acting antivirals without lipid-lowering therapy were included for comparisons of PCSK9, LAB, HDL-CUC, and other clinical indices between pretreatment and SVR12 time points. RESULTS LDL (LDL) cholesterol and HDL cholesterol levels were quantitatively increased at SVR12, along with higher PCSK9 (all p
- Subjects :
- Hepatology
Apolipoprotein B
biology
medicine.diagnostic_test
Cholesterol
business.industry
PCSK9
Pharmacology
Virus
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Infectious Diseases
High-density lipoprotein
chemistry
030220 oncology & carcinogenesis
Low-density lipoprotein
biology.protein
medicine
lipids (amino acids, peptides, and proteins)
030211 gastroenterology & hepatology
Lipid profile
business
Lipoprotein
Subjects
Details
- ISSN :
- 1872034X and 13866346
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Hepatology Research
- Accession number :
- edsair.doi.dedup.....efec89f70c93fb0297d8f6a83213ab9e