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A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn’s disease
- Source :
- Journal of Crohn's and Colitis, 1, 70-6, Journal of Crohn's and Colitis, 1, 2, pp. 70-6
- Publication Year :
- 2007
- Publisher :
- Oxford University Press (OUP), 2007.
-
Abstract
- Background and aims A recent study reported that a nonsynonymous SNP rs2241880 (c.898A>G, p.Thr300Ala) within ATG16L1 confers susceptibility to Crohn's disease (CD). We analyzed ATG16L1 c.898A>G in three independent European inflammatory bowel disease (IBD) cohorts from Germany, Hungary and the Netherlands. Methods In total, we included 910 European IBD patients and compared the ATG16L1 c.898A>G genotype frequency with 707 ethnically matched healthy controls. We included patients from 3 populations originating from Germany (CD n =310; ulcerative colitis [UC] n =179), Hungary (CD n =147; UC n =117), and the Netherlands (CD n =157). Subtyping analysis was performed in respect to CARD15 alterations and clinical characteristics. Results We found a highly significant association of c.898A>G to CD. The association was significant ( p =0.0005) for the total CD cohort but also for the individual populations from Germany ( p =0.02) and Netherlands ( p =0.02) whereas in the Hungarian CD patients a clear trend was observed ( p =0.19; OR 1.227, 95% CI 0.910; 1.654). No association was found between c.898A>G and UC. No statistical interactions were observed between ATG16L1 c.898A>G and C ARD15 variants. Furthermore no association to a CD subphenotype was detected. Conclusions We confirm that ATG16L1 variant c898A>G confers a risk variant for CD but is not associated with a distinct CD phenotype.
- Subjects :
- medicine.medical_specialty
Crohn's disease
business.industry
Gastroenterology
Membrane transport and intracellular motility [NCMLS 5]
General Medicine
Disease
medicine.disease
Inflammatory bowel disease
Ulcerative colitis
Genotype frequency
Pathogenesis and modulation of inflammation [N4i 1]
Genetic defects of metabolism [UMCN 5.1]
Internal medicine
Genotype
Cohort
Immunology
medicine
Molecular gastro-enterology and hepatology [IGMD 2]
business
ATG16L1
Subjects
Details
- ISSN :
- 18739946
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Crohn's and Colitis
- Accession number :
- edsair.doi.dedup.....efe1478a82d3b24082394e9643632a58