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LNA (locked nucleic acids)
- Source :
- Wengel, J, Koshkin, A, Singh, S K, Nielsen, P, Meldgaard, M, Rajwanshi, V K, Kumar, R, Skouv, J, Nielsen, C B & Jacobsen, J P 1999, ' LNA (locked nucleic acids) ', Nucleosides, Nucleotides and Nucleic Acids, vol. 18, no. 6-7, pp. 1365-1370 . https://doi.org/10.1080/07328319908044718, Scopus-Elsevier
- Publication Year :
- 1999
-
Abstract
- LNA (Locked Nucleic Acid) forms duplexes with complementary DNA, RNA or LNA with unprecedented thermal affinities. CD spectra show that duplexes involving fully modified LNA (especially LNA:RNA) structurally resemble an A-form RNA:RNA duplex. NMR examination of an LNA:DNA duplex confirm the 3′-endo conformation of an LNA monomer. Recognition of double-stranded DNA is demonstrated suggesting strand invasion by LNA. Lipofectin-mediated efficient delivery of LNA into living human breast cancer cells has been accomplished.
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Wengel, J, Koshkin, A, Singh, S K, Nielsen, P, Meldgaard, M, Rajwanshi, V K, Kumar, R, Skouv, J, Nielsen, C B & Jacobsen, J P 1999, ' LNA (locked nucleic acids) ', Nucleosides, Nucleotides and Nucleic Acids, vol. 18, no. 6-7, pp. 1365-1370 . https://doi.org/10.1080/07328319908044718, Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....efd9da379c12776819b4df7eb01d8468
- Full Text :
- https://doi.org/10.1080/07328319908044718