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A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein synthesis during inactivity and energy restriction in older persons
- Source :
- The American journal of clinical nutrition. 108(5)
- Publication Year :
- 2018
-
Abstract
- Background In older persons, muscle loss is accelerated during physical inactivity and hypoenergetic states, both of which are features of hospitalization. Protein supplementation may represent a strategy to offset the loss of muscle during inactivity, and enhance recovery on resumption of activity. Objective We aimed to determine if protein supplementation, with proteins of substantially different quality, would alleviate the loss of lean mass by augmenting muscle protein synthesis (MPS) while inactive during a hypoenergetic state. Design Participants (16 men, mean ± SD age: 69 ± 3 y; 15 women, mean ± SD age: 68 ± 4 y) consumed a diet containing 1.6 g protein · kg-1 · d-1, with 55% ± 9% of protein from foods and 45% ± 9% from supplements, namely, whey protein (WP) or collagen peptides (CP): 30 g each, consumed 2 times/d. Participants were in energy balance (EB) for 1 wk, then began a period of energy restriction (ER; -500 kcal/d) for 1 wk, followed by ER with step reduction (ER + SR
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Whey protein
Calorie
media_common.quotation_subject
Rest
Medicine (miscellaneous)
Muscle Proteins
Walking
Motor Activity
law.invention
03 medical and health sciences
Randomized controlled trial
law
Internal medicine
medicine
Humans
Muscle, Skeletal
media_common
Aged
Caloric Restriction
Muscle protein
Leg
030109 nutrition & dietetics
Nutrition and Dietetics
Muscle loss
business.industry
Convalescence
Protein supplementation
Hospitalization
Endocrinology
Whey Proteins
Protein Biosynthesis
Dietary Supplements
Lean body mass
Female
Collagen
business
Energy Intake
Energy Metabolism
Peptides
Subjects
Details
- ISSN :
- 19383207
- Volume :
- 108
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The American journal of clinical nutrition
- Accession number :
- edsair.doi.dedup.....efd3b4a74b7c23dfa82e76108b26406e