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Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial
- Source :
- JAMA. 296(19)
- Publication Year :
- 2006
-
Abstract
- ContextProstate safety is a primary concern when aging men receive testosterone replacement therapy (TRT), but little information is available regarding the effects of TRT on prostate tissue in men.ObjectiveTo determine the effects of TRT on prostate tissue of aging men with low serum testosterone levels.Design, Setting, and ParticipantsRandomized, double-blind, placebo-controlled trial of 44 men, aged 44 to 78 years, with screening serum testosterone levels lower than 300 ng/dL (
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
Hormone Replacement Therapy
medicine.medical_treatment
Urology
Double-Blind Method
Prostate
Internal medicine
medicine
Humans
Increased serum testosterone level
Testosterone
Age of Onset
Aged
Oligonucleotide Array Sequence Analysis
business.industry
Gene Expression Profiling
Hypogonadism
Biopsy, Needle
Prostatic Neoplasms
Dihydrotestosterone
Epithelial Cells
General Medicine
Middle Aged
Androgen
Androgen receptor
Prostate-specific antigen
Endocrinology
medicine.anatomical_structure
RNA
Androgen replacement therapy
business
medicine.drug
Subjects
Details
- ISSN :
- 15383598
- Volume :
- 296
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- JAMA
- Accession number :
- edsair.doi.dedup.....efca0fa2c189d88c3fc88fe5c7d92876