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Afamin expression in breast cancer
- Source :
- Asian Journal of Surgery, Vol 43, Iss 7, Pp 750-754 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Summary Background Breast cancer is a collection of molecularly and clinically distinct neoplastic disease. Recent research has shown the information regarding gene expression in breast cancer could be beneficial in the designing of an optimal treatment plan and may also provide with prognostic information. The creation of tissue microarrays (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in parallel with minimal damage to the original blocks. This study was designed with the application of tissue microarray (TMA) to analyze the afamin status in breast cancer with the hope of elucidating the possible relationship between afamin expressions and breast cancer. Methods Archival tissue specimens from 106 patients with primary invasive breast cancer were analyzed for afamin expression by immunhistochemical staining with TMA. Results were compared to clinicopathologic data by multivariate analysis. Results TNM stage has shown significant relationship to the overall 5-year survival rate. However, afamin expression was not significantly related to overall five-year survival. Conclusion Immunohistochemical staining with TMA was convenient and feasible for analyzing afamin expression status in breast cancer. Our preliminary results show that afamin expression showed no significant prognostic value in breast cancer.
- Subjects :
- Adult
Oncology
medicine.medical_specialty
lcsh:Surgery
Gene Expression
Breast Neoplasms
Serum Albumin, Human
Tissue microarray
03 medical and health sciences
0302 clinical medicine
Breast cancer
Afamin
Internal medicine
medicine
Humans
Stage (cooking)
Survival rate
Aged
Glycoproteins
business.industry
Optimal treatment
Neoplastic disease
Biomarker
lcsh:RD1-811
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Gene Expression Regulation, Neoplastic
Survival Rate
Tissue Array Analysis
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
030211 gastroenterology & hepatology
Surgery
Carrier Proteins
business
Negative Results
Subjects
Details
- Language :
- English
- ISSN :
- 10159584
- Volume :
- 43
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Surgery
- Accession number :
- edsair.doi.dedup.....efbf83c9b099f30c82eb6001f597d9fa