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Accurate Monitoring of the Response of Bone Metastases to Treatment in Patients with Prostate Cancer Using Choline PET/CT
- Source :
- Case Reports in Oncology, Vol 14, Iss 1, Pp 520-524 (2021), Case Reports in Oncology
- Publication Year :
- 2021
- Publisher :
- Karger Publishers, 2021.
-
Abstract
- We here report 2 cases of castration-resistant prostate cancer (CRPC) observed two times on 11C-choline positron emission tomography computed tomography (PET/CT), which was useful to discriminate viable progressive osteoblastic bone metastasis from benign osteoblastic change induced by the treatment effect and to determine the viability of bone metastases, regardless of whether sclerosis was present or not. Because one case demonstrated disappearance of abnormal 11C-choline uptake of osteoblastic metastatic lesions after abiraterone therapy and no new lesions at other sites, suggesting nonviable bone metastases, we can assume a complete metabolic response. Because the other case demonstrated a decrease in the existing, abnormal 11C-choline uptake of osteoblastic metastatic lesions, but multiple new appearances of osteoblastic and nonosteoblastic lesions with abnormal 11C-choline uptake after radium-223 therapy suggesting multiple viable bone metastases, we can assume progressive metabolic disease. 11C-choline PET/CT could help in assessing the treatment response of bone metastases in patients with metastatic CRPC.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Treatment response
Case Report
Progressive Metabolic Disease
lcsh:RC254-282
03 medical and health sciences
Prostate cancer
chemistry.chemical_compound
0302 clinical medicine
medicine
castration-resistant prostate cancer
In patient
Positron Emission Tomography-Computed Tomography
bone metastasis
business.industry
Bone metastasis
treatment response
Choline pet ct
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
choline pet/ct
Abiraterone
030104 developmental biology
Oncology
chemistry
030220 oncology & carcinogenesis
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 16626575
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Case Reports in Oncology
- Accession number :
- edsair.doi.dedup.....efba6633dced00b02439e2d74ed52e64