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Biomarker-guided therapies in heart failure: a forum for unified strategies
- Source :
- Journal of Cardiac Failure, Journal of Cardiac Failure, Elsevier, 2013, 19, pp.592-9. ⟨10.1016/j.cardfail.2013.05.012⟩, Journal of Cardiac Failure, 2013, 19, pp.592-9. ⟨10.1016/j.cardfail.2013.05.012⟩, Journal of cardiac failure, 19(8), 592-9. United States (2013).
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- The complexity of standard medical treatment for heart failure is growing, and such therapy typically involves 5 or more different medications. Given these pressures, there is increasing interest in harnessing cardiovascular biomarkers for clinical application to more effectively guide diagnosis, risk stratification, and therapy. It may be possible to realize an era of personalized medicine for heart failure treatment in which therapy is optimized and costs are controlled. The direct mechanistic coupling of biologic processes and therapies achieved in cancer treatment remains elusive in heart failure. Recent clinical trials and meta-analyses of biomarkers in heart failure have produced conflicting evidence. In this article, which comprises a summary of discussions from the Global Cardiovascular Clinical Trialists Forum held in Paris, France, we offer a brief overview of the background and rationale for biomarker testing in heart failure, describe opportunities and challenges from a regulatory perspective, and summarize current positions from government agencies in the United States and European Union.
- Subjects :
- medicine.medical_specialty
GENE POLYMORPHISM
[SDV]Life Sciences [q-bio]
030204 cardiovascular system & hematology
Pharmacology
ACUTE DYSPNEA
ADRENERGIC-RECEPTOR GENOTYPES
law.invention
BRAIN-NATRIURETIC PEPTIDE
03 medical and health sciences
biologic markers
0302 clinical medicine
Randomized controlled trial
law
ROSUVASTATIN MULTINATIONAL TRIAL
medicine
media_common.cataloged_instance
030212 general & internal medicine
European union
Intensive care medicine
media_common
Biologic marker
Government
clinical trials
business.industry
DIAGNOSTIC BIOMARKERS
ASSOCIATION
BETA(1)-ADRENERGIC RECEPTOR
medicine.disease
Systèmes cardiovasculaire & respiratoire [D03] [Sciences de la santé humaine]
RANDOMIZED-TRIAL
3. Good health
cardiovascular diseases
Clinical trial
CARDIOVASCULAR-DISEASE
Pharmacogenetics
Heart failure
Biomarker (medicine)
Personalized medicine
Cardiovascular & respiratory systems [D03] [Human health sciences]
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 10719164
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiac Failure, Journal of Cardiac Failure, Elsevier, 2013, 19, pp.592-9. ⟨10.1016/j.cardfail.2013.05.012⟩, Journal of Cardiac Failure, 2013, 19, pp.592-9. ⟨10.1016/j.cardfail.2013.05.012⟩, Journal of cardiac failure, 19(8), 592-9. United States (2013).
- Accession number :
- edsair.doi.dedup.....efb9bf63c10d2b637727d52586ff4612