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Aberrant Function and Differentiation of Monocytes in End Stage Renal Disease
- Source :
- Archivum Immunologiae et Therapiae Experimentalis. 60:453-459
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Patients with end stage renal disease (ESRD) suffer from many disturbances of the immune system. These immunopathologies are related to the higher failure of vaccination, and increased prevalence of infections and neoplasms. In the presented article, we review the current data regarding the role of monocytes in immune dysfunctions which are observed in terminal renal failure. As monocytes play a pivotal role in regulating the function of the immune system, their dysfunction can have a profound effect on the immune system and may lead to accelerated arteriosclerosis and deteriorating overall health conditions. More specifically, we suggest that peripheral blood monocytes in patients with ESRD are chronically activated, and their functional and phenotypical features resemble those of inflammatory macrophages. This state of chronic inflammation is unfavorable for dendritic cells and consequently, the prevalence of dendritic cells is reduced. As these effects are consistent across different modes of dialysis, they are probably mediated by the uremia itself.
- Subjects :
- Immunology
Inflammation
Adaptive Immunity
Monocytes
End stage renal disease
Immune system
Renal Dialysis
Immunopathology
medicine
Animals
Humans
Immunology and Allergy
Macrophage
business.industry
Monocyte
Cell Differentiation
Dendritic Cells
General Medicine
Dendritic cell
medicine.disease
Uremia
Phenotype
medicine.anatomical_structure
Kidney Failure, Chronic
Inflammation Mediators
medicine.symptom
business
Subjects
Details
- ISSN :
- 16614917 and 0004069X
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Archivum Immunologiae et Therapiae Experimentalis
- Accession number :
- edsair.doi.dedup.....efb181f488a77b3cd8e0e7d0af899ddc
- Full Text :
- https://doi.org/10.1007/s00005-012-0191-0