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Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2011
- Publisher :
- Rockefeller University Press, 2011.
-
Abstract
- MCMV-infected cells are recognized by multiple MHC class I–restricted Ly49-activating receptors in genetically distinct mouse strains.<br />Recognition of mouse cytomegalovirus (MCMV)–infected cells by activating NK cell receptors was first described in the context of Ly49H, which confers resistance to C57BL/6 mice. We investigated the ability of other activating Ly49 receptors to recognize MCMV-infected cells in mice from various H-2 backgrounds. We observed that Ly49P1 from NOD/Ltj mice, Ly49L from BALB mice, and Ly49D2 from PWK/Pas mice respond to MCMV-infected cells in the context of H-2Dk and the viral protein m04/gp34. Recognition was also seen in the H-2d and/or H-2f contexts, depending on the Ly49 receptor examined, but never in H-2b. Furthermore, BALB.K (H-2k) mice showed reduced viral loads compared with their H-2d or H-2b congenic partners, a reduction which was dependent on interferon γ secretion by Ly49L+ NK cells early after infection. Adoptive transfer of Ly49L+, but not Ly49L−, NK cells significantly increased resistance against MCMV infection in neonate BALB.K mice. These results suggest that multiple activating Ly49 receptors participate in H-2–dependent recognition of MCMV infection, providing a common mechanism of NK cell–mediated resistance against viral infection.
- Subjects :
- Muromegalovirus
Adoptive cell transfer
Viral protein
Immunology
Context (language use)
Nod
Biology
medicine.disease_cause
Article
Mice
03 medical and health sciences
0302 clinical medicine
stomatognathic system
Species Specificity
Mice, Inbred NOD
MHC class I
medicine
Animals
Immunology and Allergy
Receptor
030304 developmental biology
Mice, Inbred BALB C
0303 health sciences
Histocompatibility Antigens Class I
virus diseases
Herpesviridae Infections
Viral Load
biology.organism_classification
Virology
Immunity, Innate
3. Good health
Killer Cells, Natural
biology.protein
Viral load
NK Cell Lectin-Like Receptor Subfamily A
030215 immunology
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 208
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....efa4612a03d7e304c002ec4001efd0a0