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Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices
- Source :
- British Journal of Pharmacology. 119:1081-1083
- Publication Year :
- 1996
- Publisher :
- Wiley, 1996.
-
Abstract
- Nociceptin, an endogenous ligand for the orphan receptor ORL1, has recently been described. In this study we have shown that nociception inhibits 46 mM K(+)-stimulated glutamate release from rat perfused cerebrocortical slices with an IC50 of 51 nM. At 100 nM the inhibition amounted to 68 +/- 14% and was naloxone (10 microM)-insensitive excluding an activation of mu, delta and kappa opioid receptors. These data demonstrate the functional coupling of ORL1 in glutamatergic neurones and implicates a role for nociceptin in glutamatergic neurotransmission.
- Subjects :
- medicine.medical_specialty
Molecular Sequence Data
Glutamic Acid
(+)-Naloxone
In Vitro Techniques
Neurotransmission
chemistry.chemical_compound
Glutamatergic
Internal medicine
medicine
Animals
Amino Acid Sequence
Rats, Wistar
Neurotransmitter
Cerebral Cortex
Pharmacology
Orphan receptor
Dose-Response Relationship, Drug
Naloxone
Glutamate receptor
Glutamic acid
Rats
Nociceptin receptor
Endocrinology
Opioid Peptides
chemistry
Receptors, Opioid
Potassium
Female
Research Article
Subjects
Details
- ISSN :
- 00071188
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- British Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....ef965bc3a670c45223072e8b2a9edd44