Contrast Sensitivity Testing in Age-Related Macular Degeneration Using Motion Diamond Stimulus

Nenita Maganti,1 Natalie Squires,1 Shubhendu Mishra,1 Prithvi Bomdica,1 Divya Nigam,2 Arthur Shapiro,2 Manjot K Gill,1 Alice T Lyon,1 Rukhsana G Mirza1 1Department of Ophthalmology, Northwestern University, Chicago, IL, USA; 2Department of Psychology and Department of Computer Science, American University, Washington, DC, USACorrespondence: Rukhsana G Mirza, Department of Ophthalmology, Northwestern University, Chicago, IL, USA, Tel +1 312-908-8152, Email r-mirza@Northwestern.eduPurpose: This study was performed to characterize changes in contrast sensitivity (CS) that occur in patients with age-related macular degeneration (AMD) using a novel test, the motion diamond stimulus (MDS).Methods: This was a cross-sectional study in which 20 subjects with unilateral exudative AMD (eAMD) and contralateral dry AMD received 3 assessments: the Pelli-Robson (PR) CS Chart, the MDS test, and a visual function questionnaire-25 (VFQ-25). CS results from the PR, and MDS tests were compared across 3 groups: eyes with eAMD vs dry AMD, eAMD vs control, dry AMD vs control. Healthy, undilated eyes from another study served as the control group. Significance was determined using ANOVA analysis for the MDS output parameters (α: overall contrast threshold, β: adaptability of the visual system) and PR logCS. Patients were also administered the VFQ-25 to assess vision-related quality of life.Results: The ANOVA of the MDS data demonstrated a significant difference in visual function according to the β parameter of the 3 groups, but no significant difference in the α parameter. PR CS results for the 3 groups were significantly different, further supporting the MDS results. Post-hoc analysis showed a significant difference in β and PR log CS between the eAMD and control eyes.Conclusion: The MDS test is valuable in discerning CS impairments in patients with AMD. It can provide further insight into the visual changes experienced by patients with AMD and has potential to quantify visual function changes that are not found on visual acuity testing alone.Keywords: age-related macular degeneration, AMD, motion diamond stimulus, MDS, contrast sensitivity, CS