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Analysis of the risk of infection in patients with chronic lymphocytic leukemia in the era of novel therapies
- Source :
- Leukemialymphoma. 59(3)
- Publication Year :
- 2017
-
Abstract
- We studied the risk of infections in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). Major infections were defined as requiring hospital admission or intravenous antimicrobial treatment. Incidence rate (IR) ratios (IRR) were used to compare infection rates. Of 263 CLL patients followed for 936.9 person-years, 60% required treatment for progressive CLL (66 received ibrutinib). Infections occurred in 71.9% patients (IR 92.4/100 person-years) with 31.9% having major infections (IR 20.3/100 person-years) and infections causing 37.5% of deaths. CLL treatment was associated with significantly higher risk of major (IRR 3.31, 95% CI 2.10, 5.21) and minor (IRR 1.78, 95% CI 1.43, 2.22) infections. Compared to their previous chemoimmunotherapy patients receiving salvage ibrutinib therapy (n = 47) had a significantly increased risk of a major infection (IRR 2.35 95% CI 1.27, 4.34). The risk of infection in CLL patients remains high even with use of less immunosuppressive therapies.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Chronic lymphocytic leukemia
Communicable Diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Piperidines
Chemoimmunotherapy
Risk Factors
hemic and lymphatic diseases
Internal medicine
Medicine
Humans
In patient
Molecular Targeted Therapy
Chemotherapy
business.industry
Risk of infection
Adenine
Hematology
Middle Aged
Antimicrobial
medicine.disease
Prognosis
Leukemia, Lymphocytic, Chronic, B-Cell
Pyrimidines
Oncology
chemistry
030220 oncology & carcinogenesis
Ibrutinib
Immunology
population characteristics
Pyrazoles
Female
business
Risk assessment
030215 immunology
Follow-Up Studies
Subjects
Details
- ISSN :
- 10292403
- Volume :
- 59
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Leukemialymphoma
- Accession number :
- edsair.doi.dedup.....ef91c8912d8c29bfee611f867e04ccc8