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Inflammation, vitamin D and dendritic cell precursors in chronic kidney disease
- Source :
- Clinical and Experimental Immunology. 186:86-95
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Summary Decreased blood dendritic cell precursors (DCP) count is linked with atherosclerotic disease, while reduction of circulating DCP is also seen in patients with chronic kidney disease (CKD). As poor vitamin D status could be linked to a compromised innate immune response, we hypothesized that vitamin D status might be involved in the decrease in circulating DCP in CKD. Moreover, the potential role of inflammation was considered. Circulating myeloid (mDCP), plasmacytoid (pDCP) and total DCP (tDCP) were analysed using flow cytometry in 287 patients with CKD stage 3. Serum 25(OH)D and 1,25(OH)2D levels were measured using enzyme-linked immunosorbent assays (ELISA), interleukin (IL)-6, IL-10 and tumour necrosis factor (TNF)-α using cytometric bead array, C-reactive protein (CRP) using a high-sensitivity (hs) ELISA. Contrary to our hypothesis, there was no association between vitamin D levels and DCP, although their number was decreased significantly in CKD (P
- Subjects :
- Male
medicine.medical_specialty
Myeloid
Immunology
030232 urology & nephrology
Renal function
Cell Count
Inflammation
Comorbidity
030204 cardiovascular system & hematology
Flow cytometry
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
Vitamin D and neurology
medicine
Humans
Immunology and Allergy
Renal Insufficiency, Chronic
Vitamin D
Aged
medicine.diagnostic_test
business.industry
Stem Cells
Dendritic Cells
Original Articles
Dendritic cell
Middle Aged
medicine.disease
C-Reactive Protein
Endocrinology
medicine.anatomical_structure
Female
medicine.symptom
business
Biomarkers
Kidney disease
Subjects
Details
- ISSN :
- 13652249 and 00099104
- Volume :
- 186
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....ef9074f660f4ee46e114236c3ce5b8fe