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Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents
- Source :
- Pharmaceutical Research. 34:2156-2162
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Low oxygen levels, or hypoxemia, is a common cause of morbidity and mortality in critically ill patients. Hypoxemia is typically addressed by increasing the fraction of inspired oxygen, the use of mechanical ventilation, or more invasive measures. Recently, the injection of oxygen gas directly into the bloodstream by packaging it within lipid-based oxygen microbubbles (LOMs) has been explored. The purpose of this work is to examine the acute hemodynamic effects of intravenous injections of LOMs. LOMs composed of 1,2-distearoyl-sn-glycero-3-phosphocoline and cholesterol were manufactured using a process of shear homogenization under an oxygen headspace. A 5 mL aliquot of either PlasmaLyte A, or low (37%) or high (55%) concentration LOMs (n = 10 per group) was injected over a 1 min period into Sprague Dawley rats instrumented for measurement of cardiac index and pulmonary (PVR) and systemic (SVR) vascular resistance during a 60 min observation period. Hemodynamics were compared between groups by linear mixed modeling. Approximately 1011 LOMs with mean diameter 3.77 ± 1.19 μm were injected over the 1 min period. Relative to controls, rodents treated with high concentration LOMs exhibited a higher pulmonary artery pressure (20 ± 0.4 mmHg vs 18 ± 0.4 mmHg, P 48 h since manufacture) resulted in a higher incidence of hemodynamic collapse during the observation period (P = 0.02). LOMs may be injected in quantities sufficient to deliver clinically meaningful volumes of oxygen but cause significant decrements in blood pressure and elevations in PVR.
- Subjects :
- Male
Surface Properties
medicine.medical_treatment
Cardiac index
Pharmaceutical Science
Hemodynamics
Blood Pressure
02 engineering and technology
Pulmonary Artery
Hypoxemia
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Fraction of inspired oxygen
medicine
Animals
Humans
Pharmacology (medical)
030212 general & internal medicine
Particle Size
Hypoxia
Pharmacology
Mechanical ventilation
Microbubbles
Chemistry
Organic Chemistry
Hypoxia (medical)
021001 nanoscience & nanotechnology
Respiration, Artificial
Rats
Oxygen
Cholesterol
medicine.anatomical_structure
Blood pressure
Anesthesia
Injections, Intravenous
Phosphatidylcholines
Vascular resistance
Molecular Medicine
Vascular Resistance
medicine.symptom
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 1573904X and 07248741
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Research
- Accession number :
- edsair.doi.dedup.....ef8a4193872a3285750be981059afee3