GLUCAGON-LIKE PEPTIDE-1 RECEPTOR ACTIVATION DURING MYOCARDIAL INFARCTION REDUCES DIASTOLIC DYSFUNCTION IN PIGS

Results: Exenatide pigs showed higher PFR (0.3 ± 0.04 vs. 0.2 ± 0.1 mL/s, p < 0.05), shorter nTPFR (9.6 ± 0.9 vs. 7.4 ± 1.9, p < 0.05) and larger irst illing volume (33.9 ± 5.1 vs. 24.31 ± 4.09mL, p < 0.05). These MRI indings were supported by our echocardiography results; Exenatidetreated animals showed greater color M-mode propagation velocities (32.9 ± 2.5 vs. 25.7 ± 6.05cm/s, p < 0.05) and improved myocardial performance index (0.53 ± 0.03 vs. 0.69 ± 0.1, p < 0.05), compared to placebo. There were no differences in LV end-diastolic pressure or pulmonary capillary wedge pressure between Exenatide treatment and placebo. There was a signiicant inverse correlation between irst illing volume and histomorphometric measures of cardiomyocyte hypertrophy (r=-0.72, p