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Cerebrospinal Fluid Sulfatide Levels Lack Diagnostic Utility in the Subcortical Small Vessel Type of Dementia
- Source :
- Journal of Alzheimer's disease
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Background: Sulfatides (STs) in cerebrospinal fluid (CSF), as well as magnetic resonance imaging (MRI)-detected white matter hyperintensities (WMHs), may reflect demyelination. Here, we investigated the diagnostic utility of CSF ST levels in the subcortical small vessel type of dementia (SSVD), which is characterized by the presence of brain WMHs. Objective: To study the diagnostic utility of CSF ST levels in SSVD. Methods: This was a mono-center, cross-sectional study of SSVD (n = 16), Alzheimer’s disease (n = 40), mixed dementia (n = 27), and healthy controls (n = 33). Totally, 20 ST species were measured in CSF by liquid chromatography-mass spectrometry (LC-MS/MS). Results: CSF total ST levels, as well as CSF levels of hydroxylated and nonhydroxylated ST species, did not differ across the study groups. In contrast, CSF neurofilament light chain (NFL) levels separated the patient groups from the controls. CSF total ST level correlated with CSF/serum albumin ratio in the total study population (r = 0.64, p
- Subjects :
- Male
0301 basic medicine
subcortical small vessel type of dementia
sulfatide species
Gastroenterology
mixed dementia
0302 clinical medicine
Cerebrospinal fluid
Neurofilament Proteins
medicine.diagnostic_test
biology
General Neuroscience
General Medicine
white matter hyperintensities
Magnetic Resonance Imaging
White Matter
Psychiatry and Mental health
Clinical Psychology
Population study
Biomarker (medicine)
Female
Alzheimer’s disease
medicine.medical_specialty
Neuroscience(all)
Serum albumin
Diagnostic Techniques, Neurological
cerebrospinal fluid
Diagnosis, Differential
03 medical and health sciences
Alzheimer Disease
Internal medicine
medicine
Humans
Dementia
Aged
Sulfoglycosphingolipids
business.industry
Dementia, Vascular
Reproducibility of Results
Magnetic resonance imaging
medicine.disease
Hyperintensity
Cross-Sectional Studies
030104 developmental biology
sulfatides
biology.protein
Human medicine
Small vessel
Geriatrics and Gerontology
business
Procedures and Techniques Utilization
030217 neurology & neurosurgery
Chromatography, Liquid
Demyelinating Diseases
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....ef6848f71a58472d1d6ab65343e57456